Betaine transporter

BCCT family transporter
Identifiers
Symbol BCCT
Pfam PF02028
InterPro IPR000060
TCDB 2.A.15
OPM family 67
OPM protein 3fhx

Betaine / Carnitine / Choline Transporters (BCCT) are a family of prokaryotic transport proteins that are specific for compounds containing a quaternary nitrogen atom. The BCCT proteins contain 12 transmembrane regions and are energized by proton symport. They contain a conserved region with four tryptophans in their central region[1].

The mammalian betaine transporter (SLC6A12) is regulated by NFAT5 during response to osmotic stress.[2]

References

  1. ^ Kempf B, Bremer E, Kappes RM (1996). "Three transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD". J. Bacteriol. 178 (17): 5071–5079. PMID 8752321. 
  2. ^ Lee, S. D.; Choi, S. Y.; Lim, S. W.; Lamitina, S. T.; Ho, S. N.; Go, W. Y.; Kwon, H. M. (2011). "TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways". AJP: Renal Physiology 300 (3): F707–F715. doi:10.1152/ajprenal.00227.2010. PMC 3064130. PMID 21209002. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3064130.  edit

This article incorporates text from the public domain Pfam and InterPro IPR000060